Serveur d'exploration sur la COVID en France

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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Identifieur interne : 000A24 ( Main/Exploration ); précédent : 000A23; suivant : 000A25

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Auteurs : Jerome R. Lechien [France, Belgique] ; Carlos M. Chiesa-Estomba [France, Espagne] ; Daniele R. De Siati [France, Belgique] ; Mihaela Horoi [Belgique] ; Serge D. Le Bon [Belgique] ; Alexandra Rodriguez [Belgique] ; Didier Dequanter [Belgique] ; Serge Blecic [Belgique] ; Fahd El Afia [France] ; Lea Distinguin [France] ; Younes Chekkoury-Idrissi [France] ; Stéphane Hans [France] ; Irene Lopez Delgado [France, Espagne] ; Christian Calvo-Henriquez [France, Espagne] ; Philippe Lavigne [France, Canada] ; Chiara Falanga [France, Italie] ; Maria Rosaria Barillari [France, Italie] ; Giovanni Cammaroto [France, Italie] ; Mohamad Khalife [Belgique] ; Pierre Leich [Belgique] ; Christel Souchay [Belgique] ; Camelia Rossi [Belgique] ; Fabrice Journe [Belgique] ; Julien Hsieh [France, Suisse] ; Myriam Edjlali [France] ; Robert Carlier [France] ; Laurence Ris [Belgique] ; Andrea Lovato [Italie] ; Cosimo De Filippis [Italie] ; Frederique Coppee [Belgique] ; Nicolas Fakhry [France] ; Tareck Ayad [France, Canada] ; Sven Saussez [France, Belgique]

Source :

RBID : pubmed:32253535

Descripteurs français

English descriptors

Abstract

OBJECTIVE

To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection.

METHODS

Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).

RESULTS

A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001).

CONCLUSION

Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.


DOI: 10.1007/s00405-020-05965-1
PubMed: 32253535
PubMed Central: PMC7134551


Affiliations:


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<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation>
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<name sortKey="De Siati, Daniele R" sort="De Siati, Daniele R" uniqKey="De Siati D" first="Daniele R" last="De Siati">Daniele R. De Siati</name>
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<name sortKey="Rodriguez, Alexandra" sort="Rodriguez, Alexandra" uniqKey="Rodriguez A" first="Alexandra" last="Rodriguez">Alexandra Rodriguez</name>
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<country xml:lang="fr">Belgique</country>
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<name sortKey="Blecic, Serge" sort="Blecic, Serge" uniqKey="Blecic S" first="Serge" last="Blecic">Serge Blecic</name>
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<name sortKey="El Afia, Fahd" sort="El Afia, Fahd" uniqKey="El Afia F" first="Fahd" last="El Afia">Fahd El Afia</name>
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<country xml:lang="fr">France</country>
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<name sortKey="Distinguin, Lea" sort="Distinguin, Lea" uniqKey="Distinguin L" first="Lea" last="Distinguin">Lea Distinguin</name>
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<country xml:lang="fr">France</country>
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<name sortKey="Chekkoury Idrissi, Younes" sort="Chekkoury Idrissi, Younes" uniqKey="Chekkoury Idrissi Y" first="Younes" last="Chekkoury-Idrissi">Younes Chekkoury-Idrissi</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name>
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<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<name sortKey="Delgado, Irene Lopez" sort="Delgado, Irene Lopez" uniqKey="Delgado I" first="Irene Lopez" last="Delgado">Irene Lopez Delgado</name>
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<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Quironsalud Valencia, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Quironsalud Valencia, Valencia</wicri:regionArea>
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<author>
<name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
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<nlm:affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela</wicri:regionArea>
<wicri:noRegion>Santiago de Compostela</wicri:noRegion>
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<author>
<name sortKey="Lavigne, Philippe" sort="Lavigne, Philippe" uniqKey="Lavigne P" first="Philippe" last="Lavigne">Philippe Lavigne</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="1">
<nlm:affiliation>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
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<name sortKey="Falanga, Chiara" sort="Falanga, Chiara" uniqKey="Falanga C" first="Chiara" last="Falanga">Chiara Falanga</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
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<settlement type="city">Paris</settlement>
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<affiliation wicri:level="1">
<nlm:affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
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<author>
<name sortKey="Barillari, Maria Rosaria" sort="Barillari, Maria Rosaria" uniqKey="Barillari M" first="Maria Rosaria" last="Barillari">Maria Rosaria Barillari</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea>
<wicri:noRegion>Forli</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Khalife, Mohamad" sort="Khalife, Mohamad" uniqKey="Khalife M" first="Mohamad" last="Khalife">Mohamad Khalife</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour</wicri:regionArea>
<wicri:noRegion>Baudour</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leich, Pierre" sort="Leich, Pierre" uniqKey="Leich P" first="Pierre" last="Leich">Pierre Leich</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Souchay, Christel" sort="Souchay, Christel" uniqKey="Souchay C" first="Christel" last="Souchay">Christel Souchay</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rossi, Camelia" sort="Rossi, Camelia" uniqKey="Rossi C" first="Camelia" last="Rossi">Camelia Rossi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Infectious Disease, CHU Ambroise-Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Division of Infectious Disease, CHU Ambroise-Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Journe, Fabrice" sort="Journe, Fabrice" uniqKey="Journe F" first="Fabrice" last="Journe">Fabrice Journe</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Edjlali, Myriam" sort="Edjlali, Myriam" uniqKey="Edjlali M" first="Myriam" last="Edjlali">Myriam Edjlali</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Neuroradiology, Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroradiology, Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carlier, Robert" sort="Carlier, Robert" uniqKey="Carlier R" first="Robert" last="Carlier">Robert Carlier</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ris, Laurence" sort="Ris, Laurence" uniqKey="Ris L" first="Laurence" last="Ris">Laurence Ris</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Neurosciences, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Neurosciences, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lovato, Andrea" sort="Lovato, Andrea" uniqKey="Lovato A" first="Andrea" last="Lovato">Andrea Lovato</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Neuroscience, Audiology Unit, Padova University, Treviso, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience, Audiology Unit, Padova University, Treviso</wicri:regionArea>
<wicri:noRegion>Treviso</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Filippis, Cosimo" sort="De Filippis, Cosimo" uniqKey="De Filippis C" first="Cosimo" last="De Filippis">Cosimo De Filippis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Neuroscience, Audiology Unit, Padova University, Treviso, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience, Audiology Unit, Padova University, Treviso</wicri:regionArea>
<wicri:noRegion>Treviso</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Coppee, Frederique" sort="Coppee, Frederique" uniqKey="Coppee F" first="Frederique" last="Coppee">Frederique Coppee</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Metabolic and Molecular Biochemistry, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Metabolic and Molecular Biochemistry, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ayad, Tareck" sort="Ayad, Tareck" uniqKey="Ayad T" first="Tareck" last="Ayad">Tareck Ayad</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour</wicri:regionArea>
<wicri:noRegion>Baudour</wicri:noRegion>
</affiliation>
</author>
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<idno type="doi">10.1007/s00405-020-05965-1</idno>
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<analytic>
<title xml:lang="en">Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.</title>
<author>
<name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. Jerome.Lechien@umons.ac.be.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Jerome.Lechien@umons.ac.be.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France. Jerome.Lechien@umons.ac.be.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium. Jerome.Lechien@umons.ac.be.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Siati, Daniele R" sort="De Siati, Daniele R" uniqKey="De Siati D" first="Daniele R" last="De Siati">Daniele R. De Siati</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author>
<name sortKey="Horoi, Mihaela" sort="Horoi, Mihaela" uniqKey="Horoi M" first="Mihaela" last="Horoi">Mihaela Horoi</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author>
<name sortKey="Le Bon, Serge D" sort="Le Bon, Serge D" uniqKey="Le Bon S" first="Serge D" last="Le Bon">Serge D. Le Bon</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author>
<name sortKey="Rodriguez, Alexandra" sort="Rodriguez, Alexandra" uniqKey="Rodriguez A" first="Alexandra" last="Rodriguez">Alexandra Rodriguez</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author>
<name sortKey="Dequanter, Didier" sort="Dequanter, Didier" uniqKey="Dequanter D" first="Didier" last="Dequanter">Didier Dequanter</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author>
<name sortKey="Blecic, Serge" sort="Blecic, Serge" uniqKey="Blecic S" first="Serge" last="Blecic">Serge Blecic</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Neurology, EpiCURA Hospital, Ath, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Neurology, EpiCURA Hospital, Ath</wicri:regionArea>
<wicri:noRegion>Ath</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="El Afia, Fahd" sort="El Afia, Fahd" uniqKey="El Afia F" first="Fahd" last="El Afia">Fahd El Afia</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Distinguin, Lea" sort="Distinguin, Lea" uniqKey="Distinguin L" first="Lea" last="Distinguin">Lea Distinguin</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chekkoury Idrissi, Younes" sort="Chekkoury Idrissi, Younes" uniqKey="Chekkoury Idrissi Y" first="Younes" last="Chekkoury-Idrissi">Younes Chekkoury-Idrissi</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Delgado, Irene Lopez" sort="Delgado, Irene Lopez" uniqKey="Delgado I" first="Irene Lopez" last="Delgado">Irene Lopez Delgado</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Quironsalud Valencia, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Quironsalud Valencia, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela</wicri:regionArea>
<wicri:noRegion>Santiago de Compostela</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lavigne, Philippe" sort="Lavigne, Philippe" uniqKey="Lavigne P" first="Philippe" last="Lavigne">Philippe Lavigne</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Falanga, Chiara" sort="Falanga, Chiara" uniqKey="Falanga C" first="Chiara" last="Falanga">Chiara Falanga</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barillari, Maria Rosaria" sort="Barillari, Maria Rosaria" uniqKey="Barillari M" first="Maria Rosaria" last="Barillari">Maria Rosaria Barillari</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea>
<wicri:noRegion>Forli</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Khalife, Mohamad" sort="Khalife, Mohamad" uniqKey="Khalife M" first="Mohamad" last="Khalife">Mohamad Khalife</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour</wicri:regionArea>
<wicri:noRegion>Baudour</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leich, Pierre" sort="Leich, Pierre" uniqKey="Leich P" first="Pierre" last="Leich">Pierre Leich</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Souchay, Christel" sort="Souchay, Christel" uniqKey="Souchay C" first="Christel" last="Souchay">Christel Souchay</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rossi, Camelia" sort="Rossi, Camelia" uniqKey="Rossi C" first="Camelia" last="Rossi">Camelia Rossi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Infectious Disease, CHU Ambroise-Paré, Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Division of Infectious Disease, CHU Ambroise-Paré, Mons</wicri:regionArea>
<wicri:noRegion>Mons</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Journe, Fabrice" sort="Journe, Fabrice" uniqKey="Journe F" first="Fabrice" last="Journe">Fabrice Journe</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Edjlali, Myriam" sort="Edjlali, Myriam" uniqKey="Edjlali M" first="Myriam" last="Edjlali">Myriam Edjlali</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Neuroradiology, Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroradiology, Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carlier, Robert" sort="Carlier, Robert" uniqKey="Carlier R" first="Robert" last="Carlier">Robert Carlier</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ris, Laurence" sort="Ris, Laurence" uniqKey="Ris L" first="Laurence" last="Ris">Laurence Ris</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Neurosciences, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Neurosciences, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lovato, Andrea" sort="Lovato, Andrea" uniqKey="Lovato A" first="Andrea" last="Lovato">Andrea Lovato</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Neuroscience, Audiology Unit, Padova University, Treviso, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience, Audiology Unit, Padova University, Treviso</wicri:regionArea>
<wicri:noRegion>Treviso</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Filippis, Cosimo" sort="De Filippis, Cosimo" uniqKey="De Filippis C" first="Cosimo" last="De Filippis">Cosimo De Filippis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Neuroscience, Audiology Unit, Padova University, Treviso, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience, Audiology Unit, Padova University, Treviso</wicri:regionArea>
<wicri:noRegion>Treviso</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Coppee, Frederique" sort="Coppee, Frederique" uniqKey="Coppee F" first="Frederique" last="Coppee">Frederique Coppee</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Metabolic and Molecular Biochemistry, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Metabolic and Molecular Biochemistry, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name>
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<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
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<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<affiliation wicri:level="3">
<nlm:affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
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<name sortKey="Ayad, Tareck" sort="Ayad, Tareck" uniqKey="Ayad T" first="Tareck" last="Ayad">Tareck Ayad</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name>
<affiliation wicri:level="3">
<nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea>
<orgName type="university">Université de Mons</orgName>
<placeName>
<settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Hainaut</region>
</placeName>
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<nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
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</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
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<nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour</wicri:regionArea>
<wicri:noRegion>Baudour</wicri:noRegion>
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<title level="j">European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery</title>
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<term>Adult (MeSH)</term>
<term>Ageusia (epidemiology)</term>
<term>Ageusia (etiology)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Coronavirus (isolation & purification)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Cough (epidemiology)</term>
<term>Cough (etiology)</term>
<term>Europe (epidemiology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Myalgia (epidemiology)</term>
<term>Myalgia (etiology)</term>
<term>Nutrition Surveys (MeSH)</term>
<term>Olfaction Disorders (epidemiology)</term>
<term>Olfaction Disorders (etiology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Prevalence (MeSH)</term>
<term>Smell (MeSH)</term>
<term>Taste (MeSH)</term>
<term>Taste Disorders (MeSH)</term>
</keywords>
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<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Agueusie (épidémiologie)</term>
<term>Agueusie (étiologie)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Coronavirus (isolement et purification)</term>
<term>Enquêtes nutritionnelles (MeSH)</term>
<term>Europe (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Goût (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Myalgie (épidémiologie)</term>
<term>Myalgie (étiologie)</term>
<term>Mâle (MeSH)</term>
<term>Odorat (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Prévalence (MeSH)</term>
<term>Toux (épidémiologie)</term>
<term>Toux (étiologie)</term>
<term>Troubles de l'olfaction (épidémiologie)</term>
<term>Troubles de l'olfaction (étiologie)</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
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<term>Ageusia</term>
<term>Coronavirus Infections</term>
<term>Cough</term>
<term>Myalgia</term>
<term>Olfaction Disorders</term>
<term>Pneumonia, Viral</term>
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<term>Ageusia</term>
<term>Cough</term>
<term>Myalgia</term>
<term>Olfaction Disorders</term>
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<term>Coronavirus</term>
</keywords>
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<term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Agueusie</term>
<term>Europe</term>
<term>Infections à coronavirus</term>
<term>Myalgie</term>
<term>Pneumopathie virale</term>
<term>Toux</term>
<term>Troubles de l'olfaction</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Agueusie</term>
<term>Myalgie</term>
<term>Toux</term>
<term>Troubles de l'olfaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Betacoronavirus</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutrition Surveys</term>
<term>Pandemics</term>
<term>Prevalence</term>
<term>Smell</term>
<term>Taste</term>
<term>Taste Disorders</term>
</keywords>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Enquêtes nutritionnelles</term>
<term>Femelle</term>
<term>Goût</term>
<term>Humains</term>
<term>Mâle</term>
<term>Odorat</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVE</b>
</p>
<p>To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM">
<PMID Version="1">32253535</PMID>
<DateCompleted>
<Year>2020</Year>
<Month>07</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1434-4726</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>277</Volume>
<Issue>8</Issue>
<PubDate>
<Year>2020</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery</Title>
<ISOAbbreviation>Eur Arch Otorhinolaryngol</ISOAbbreviation>
</Journal>
<ArticleTitle>Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.</ArticleTitle>
<Pagination>
<MedlinePgn>2251-2261</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00405-020-05965-1</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Lechien</LastName>
<ForeName>Jerome R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. Jerome.Lechien@umons.ac.be.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Jerome.Lechien@umons.ac.be.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France. Jerome.Lechien@umons.ac.be.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium. Jerome.Lechien@umons.ac.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chiesa-Estomba</LastName>
<ForeName>Carlos M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>De Siati</LastName>
<ForeName>Daniele R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Horoi</LastName>
<ForeName>Mihaela</ForeName>
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<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Rodriguez</LastName>
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<Initials>A</Initials>
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<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
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<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Blecic</LastName>
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<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, EpiCURA Hospital, Ath, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>El Afia</LastName>
<ForeName>Fahd</ForeName>
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</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation>
</AffiliationInfo>
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</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation>
</AffiliationInfo>
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<LastName>Chekkoury-Idrissi</LastName>
<ForeName>Younes</ForeName>
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<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation>
</AffiliationInfo>
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<LastName>Hans</LastName>
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<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation>
</AffiliationInfo>
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<LastName>Delgado</LastName>
<ForeName>Irene Lopez</ForeName>
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<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Quironsalud Valencia, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Calvo-Henriquez</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lavigne</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Otolaryngology-Head and Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Falanga</LastName>
<ForeName>Chiara</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Barillari</LastName>
<ForeName>Maria Rosaria</ForeName>
<Initials>MR</Initials>
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<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</Affiliation>
</AffiliationInfo>
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<Initials>G</Initials>
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<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otolaryngology-Head and Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</Affiliation>
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<ForeName>Pierre</ForeName>
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<Affiliation>Department of Otolaryngology-Head and Neck Surgery, CHU Ambroise Paré, Mons, Belgium.</Affiliation>
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</AffiliationInfo>
<AffiliationInfo>
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<Affiliation>Department of Neuroradiology, Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris, France.</Affiliation>
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<Affiliation>Department of Radiology, APHP, Hôpitaux R. Poincaré-Ambroise Paré, DMU Smart Imaging, GH Université Paris-Saclay, U 1179 UVSQ/Paris-Saclay, Paris, France.</Affiliation>
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<Affiliation>Department of Neurosciences, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation>
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</Author>
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<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Neuroscience, Audiology Unit, Padova University, Treviso, Italy.</Affiliation>
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</Author>
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<AffiliationInfo>
<Affiliation>Department of Metabolic and Molecular Biochemistry, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation>
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</Author>
<Author ValidYN="Y">
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<ForeName>Nicolas</ForeName>
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<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</Affiliation>
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</Author>
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<LastName>Ayad</LastName>
<ForeName>Tareck</ForeName>
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<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
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</AffiliationInfo>
</Author>
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<ForeName>Sven</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Baudour, Belgium.</Affiliation>
</AffiliationInfo>
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<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<KeywordList Owner="NOTNLM">
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<Keyword MajorTopicYN="N">COVID</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">Dysgeusia</Keyword>
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<Keyword MajorTopicYN="N">Gustatory</Keyword>
<Keyword MajorTopicYN="N">Hyposmia</Keyword>
<Keyword MajorTopicYN="N">Infection</Keyword>
<Keyword MajorTopicYN="N">Loss</Keyword>
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<li>Italie</li>
<li>Suisse</li>
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<li>Provence-Alpes-Côte d'Azur</li>
<li>Province de Hainaut</li>
<li>Région de Bruxelles-Capitale</li>
<li>Région wallonne</li>
<li>Île-de-France</li>
</region>
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<li>Bruxelles</li>
<li>Liège</li>
<li>Marseille</li>
<li>Paris</li>
</settlement>
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<li>Université catholique de Louvain</li>
<li>Université de Mons</li>
<li>Université libre de Bruxelles</li>
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<name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name>
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<name sortKey="Barillari, Maria Rosaria" sort="Barillari, Maria Rosaria" uniqKey="Barillari M" first="Maria Rosaria" last="Barillari">Maria Rosaria Barillari</name>
<name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name>
<name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name>
<name sortKey="Carlier, Robert" sort="Carlier, Robert" uniqKey="Carlier R" first="Robert" last="Carlier">Robert Carlier</name>
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<name sortKey="Chekkoury Idrissi, Younes" sort="Chekkoury Idrissi, Younes" uniqKey="Chekkoury Idrissi Y" first="Younes" last="Chekkoury-Idrissi">Younes Chekkoury-Idrissi</name>
<name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name>
<name sortKey="De Siati, Daniele R" sort="De Siati, Daniele R" uniqKey="De Siati D" first="Daniele R" last="De Siati">Daniele R. De Siati</name>
<name sortKey="Delgado, Irene Lopez" sort="Delgado, Irene Lopez" uniqKey="Delgado I" first="Irene Lopez" last="Delgado">Irene Lopez Delgado</name>
<name sortKey="Distinguin, Lea" sort="Distinguin, Lea" uniqKey="Distinguin L" first="Lea" last="Distinguin">Lea Distinguin</name>
<name sortKey="Distinguin, Lea" sort="Distinguin, Lea" uniqKey="Distinguin L" first="Lea" last="Distinguin">Lea Distinguin</name>
<name sortKey="Edjlali, Myriam" sort="Edjlali, Myriam" uniqKey="Edjlali M" first="Myriam" last="Edjlali">Myriam Edjlali</name>
<name sortKey="Edjlali, Myriam" sort="Edjlali, Myriam" uniqKey="Edjlali M" first="Myriam" last="Edjlali">Myriam Edjlali</name>
<name sortKey="El Afia, Fahd" sort="El Afia, Fahd" uniqKey="El Afia F" first="Fahd" last="El Afia">Fahd El Afia</name>
<name sortKey="El Afia, Fahd" sort="El Afia, Fahd" uniqKey="El Afia F" first="Fahd" last="El Afia">Fahd El Afia</name>
<name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name>
<name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name>
<name sortKey="Falanga, Chiara" sort="Falanga, Chiara" uniqKey="Falanga C" first="Chiara" last="Falanga">Chiara Falanga</name>
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<name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name>
<name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name>
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